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NUCALA (mepolizumab) is an interleukin-5 (IL-5) antagonist monoclonal antibody (IgG1 kappa) indicated for:
Add-on maintenance treatment of adult and pediatric patients aged 6 years and older with severe asthma and with an eosinophilic phenotype;
Add-on maintenance treatment of adult patients 18 years and older with chronic rhinosinusitis with nasal polyps (CRSwNP);
The treatment of adult patients with eosinophilic granulomatosis with polyangiitis (EGPA);
The treatment of adult and pediatric patients aged 12 years and older with hypereosinophilic syndrome (HES) for greater than or equal to 6 months without an identifiable non-hematologic secondary cause.