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Celltrion launches Actemra® Biosimilar Avtozma®

by Leah Watson; Robert S. Schwartz, Ph.D.
October 4, 2025

On October 2, 2025, Celltrion launched Avtozma® (tocilizumab-anoh), in intravenous and subcutaneous formulations, as the third biosimilar of Genentech’s Actemra® (tocilizumab). Avtozma® was approved by the FDA on January 24, 2025 (previously reported FDA Approves Third Actemra® Biosimilar, Celltrion’s Avtozma® (tocilizumab-anoh)). Fresenius Kabi’s Tyenne® (tocilizumab-aazg) launched in April 2024 and Biogen / Bio-Thera’s Tofidence™ (tocilizumab-bavi) launched in May 2024.

There are currently no pending patent disputes related to Actemra® biosimilars.

Roche reported U.S. sales of approximately $1.476B USD (1.331B CHF) for Actemra® in 2024.

For more information on this and other biosimilar launches, please visit BiologicsHQ.com.

 

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The authors would like to thank April Breyer Menon for her contributions to this article.

    Methodology

    Information contained in the Venable BiologicsHQ database relates to FDA-approved drug products listed in the CDER Purple Book or on the FDA website (www.fda.gov). Information relating to FDA licensed products, FDA-approved indications, and aBLA and 505(b)(2) applications is obtained from public sources including the U.S. FDA website (www.fda.gov). Information relating to litigations is given only for cases active from January 31, 2010 onward. Information relating to foreign biosimilar / biologics follow-on products approved in Australia, Canada, the E.U., Japan and South Korea is from public sources. Statistics graphics are compiled from information contained in the Venable BiologicsHQ database.

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